OMF - Madison Paskell, 16, Type B-cell acute lymphoblastic leukemia, East Bridgewater with Dr. Andrew Place, Associate Director of Developmental Therapeutics, Pediatric Hematologic Malignancy Program, Dana-Farber 8-21-18

In March, Madison had repetitive sinus and ear infections and long-term abdominal pain. Her pediatrician decided to conduct blood work and found abnormal results. Further tests and procedures confirmed that Madison had leukemia.

Her treatment has consisted of many different rounds of chemotherapy, steroids, bone marrow biopsies, and lumbar punctures.

Madison's family includes her mother, Julie, 38, father, Chris, 39, and sister, Kennedy, 6.

Madison is a rising junior at East Bridgewater Junior Senior High School. In her spare time, she loves hanging out with her friends and family.

Her favorite part of the Jimmy Fund Clinic is hanging out with the nurses. She also loves Dr. Place for his sense of humor throughout her treatment.

Dr. Place specializes in the treatment of childhood leukemia and lymphoma.  Dr. Place is also a clinical investigator studying novel targeted therapies in relapsed acute leukemia.

He is a nationally recognized clinical trialist in pediatric oncology and serves on leadership committees of several large consortia including the Dana-Farber Cancer Institute ALL Consortium, the Therapeutic Advances in Childhood Leukemia Consortium and the Children’s Oncology Group. 

Dr. Place is also the Chief Medical Officer of the Institutional Centers for Clinical and Translational Research at Boston Children’s Hospital. 

Dr. Place earned his MD and PhD degrees at Dartmouth College prior to completing his Pediatric Residency and Pediatric Hematology/Oncology fellowship at Boston Children’s Hospital and the Dana-Farber Cancer Institute.  Dr. Place joined the Pediatric Hematology/Oncology faculty in 2012.

Transcript - Not for consumer use. Robot overlords only. Will not be accurate.

8777381234. Out of our phone ever going to be a lot. Of the patients and doctors throughout the afternoon as you did this morning during a mid day and this is Madison Pascal sixteen years of it. For me sport drug great to meet you. And doctor anyplace else here is what gets it. How are you again exactly see how I don't know what this was an author yeah. I don't file asking doctors call. It as a sure. Music you've got to use. Yeah. Colors. In Madison is dealing with the I be so you limbo. 10. Well last thing licked went on I can now a lot of help them candy. What does it say how well against holiday Ella you're gonna hear a LL from a lot of these kids during the course of the days suppose what happened when did you first. Now what do you view. That you know there was some. The wrong I was having a lot of like stomach pain. And it a couple of days later we tops on the general and they test flying and everything on the screen was red. Any symptoms and and and and what happened from there and then the next. Thing you know me I'm. So you're just you just have look at your infection or something and yeah it is normal to would have maybe it's Amber's here and their finger allocate space and drops some power and all and he sees the ball misses. Very close to what you thought it was so. So many. You see that he sees red when you find out what they're about to tell you the diagnosis U member. What that moment is like as I can even imagine being eureka and here at doctors say things like this. Rack. And they think about like all of evening marks I lost things. Your little sister. That you're very that your parents. We admit you were just that we were over at the the clinic awhile back are you feeling. Good. The scarf. Yeah highly indeed did the doctor doctor places a nationally recognized the political trial so you tell us what advances that we making here. And ayello we are or we now vs let's take 23 years ago four years ago. You have. The flip side of of the unfortunate news of having to. You know tell patients that they have cancer is really there's never been better data bailout and today. And that's really. A tribute to all the remarkable research that has happened idle it in a former Boston children's but it. Lots of consortium and corporate groups. And so were really learning more more about each individual patients leukemia and are able to really tailor the intensity. Of the therapy. To give them the best chance of cure well ultimately try to reduces me long term side effects we can't. It made things meter and it though quality start finding people US doctors will lose. Is diagnosed four years ago to ten years five years two years ago when did that being changed colors treating Yale yeah it became really became the we can't change about the 1970s. Where we got to the general week that was. And definitely it. But if but we started to understand that the best way to make this disease go away and come back was to combined chemotherapy. I can't understand how to safely and effectively. And really since the 1970s. We've been able to make war more progress with a single trial. And were at a point now where we can really. To our best to identify the patients who need the most chemotherapy. To give them the best exit door while limiting. The most intense chemotherapy for patients. So that's really remarkable. And giving these kids chance to tolerate there is that they can't or not just giving back a few months or years of life but the ten years record go have a completely normal. It even knows different treatment to five years ago. The drastic. It's it's more tailored for for patients who have really hard to treat leukemia. Unfortunately there's still a percentage of patients who despite their best efforts first diagnosed salute he comes back. There's a real problem where water in there he's there and available to children. And over time will learn how to incorporate those exciting treatments that we use for the most high risk patients incorporate that patients were diagnosed and they have to experience. Spanish and how we view this relationship with the doctor and how it is me you're journey a lot easier to. One of our research producers said that you think that doctors in places very fun. Has he told us we do joke. We don't we don't know is it affect so I got to believe that that relationship I want it done for you has been remarkable compressed and it was good enough. So tell us about your relationship and now he has made you not only fuel better. You know physically but emotionally as well. He is brings it and helps get through a lot of joked that souvenir hunting camp and. Leo yeah I've been totally they have a lot of gadgets now. You say there other dead on with different. That nobody's said we've we've been accused him at the clinic in obscures what is your experience. Like there you know matching go in there is not a great experience but as far as dealing with the nurses and the people there to help our out of it may. Eddie's here there are all very nice and very helpful and me to come up to you and ask you do things. Adding that helps get to that what's what some of those the best things that you've done so far. It's doing a fitting way out of the ordinary so it may not similarly simple let's just made you feel better. Just sunglasses. And axes are very nice and helpful so this happened you found out and march rate them. Of this year and yes. And as it disrupted your your teenage life that on a little an easy re and it's important time in your life yeah a little bit some things I can't do. Because like changes in south. Not much my friends are Aaland. And my. Different if you go to the clinic in here yet so they I'll see guys that are a little corner Regan there humanitarian on yet but that didn't. That's one question a dark woman or. Punctures avert a lot of treatment what you want or punctures. I'm so it turns out that one of the places this type of leukemia can hide. And be resistant to treatment isn't fluid that surrounds your brain and spinal cord which is. Through spinal fluid. I'm and so lumbar puncture is is sort of a medical term for Spinal Tap. And so because leukemia tends to hide there we have to actually give chemotherapy into that circle spinal fluid and after the procedure or. Unbelievable amazing do what you guys do and counsel simple yes. And I know it is and so on national ballot footer on the brain and we'll do everything is simple guy all our presidents and applauded if it. Restaurants threatened medicine it's great seeing you again OK to continue great health OK okay thank you very much excellence we've got guys.